In this paper, a simulation strategy to ensure pipeline integrity is proposed. Computational fracture mechanics methods are presented to acquire a more profound understanding of toughness requirements and ductile crack propagation in pipeline steels. The ability of current computer codes to estimate J-integrals is demonstrated by the simulation of compact tension tests. Then, the Gurson-Needleman-Tvergaard damage model is applied to predict crack propagation during Charpy impact experiments, where notched tensile tests were performed to calibrate the material model parameters. In addition, a brief review of cohesive zone models is presented to simulate crack propagation and arrest in high pressure gas pipelines. Case studies on composite crack arrestors and mitigation measures to address vortex induced vibrations will endorse the merits of finite element analysis in pipeline design.