A section of the Caño Limon – Coveñas crude oil pipeline (operated by Ecopetrol, Colombia) has been re-assessed and evaluated with focus on potential hazards. Based on results of oil spill quantity calculations, Ecopetrol had previously elaborated measures to mitigate potential emergency cases. High-Consequence Areas had been identified and defined. ILF Consulting Engineers were requested to develop so-called Controlled Operational Emergency Shut-Down (COESD) procedures, and to verify these numerically utilising a pipeline hydraulic simulation model. Previously defined emergency response procedures have been confirmed and optimised. This article presents the main outcome of a joint project of Ecopetrol S.A., Bogotá, Colombia, and ILF Consulting Engineers, Munich, Germany performing a Segmentation Study for a 93 km long pipeline section through a, not only hydraulically, challenging area.